By understanding emptiness, by clearly perceiving the empty nature of all phenomena, including ourselves, we can liberate ourselves from negative emotions, and thus from the creation of unwholesome karma and the power of the internal enemy. Through this process, we can begin to undo the harm we've caused by our grasping, and the derivative strong emotions to which it gives rise. The moment we begin to develop insight into the empty nature of self and all reality, the process of releasing our deluded grasp begins. At the moment of our first insight into the empty nature of self and reality, we start to break free of the enslavement of ignorance and the attack of the internal enemy. By reducing our grasping, we start to undo the causal chain of unenlightened existence. By undermining self-grasping ignorance, the first link of dependent origination, you prevent the arising of the second link, and ultimately become free of the endless cycle of suffering lifetimes. But what does all this mean exactly? If we arrive at the knowledge that the self at which we grasp is empty, we may imagine this means that we as individuals with personal identities do not exist. But of course this is not the case--our own personal experiences demonstrate that as subjects and agents of our own lives, we certainly exist. So how, then, do we understand the content of this insight into absence of self? What follows from this insight? We must be very clear that 'only the self that is being grasped as intrinsically real' needs to be negated. The self as a conventional phenomenon is not rejected. This is a crucial aspect of the Buddha's teachings on emptiness.

---from "Essence of the Heart Sutra: The Dalai Lama's Heart of Wisdom Teachings" by H.H. the Dalai Lama, translated & edited by Geshe Thupten Jinpa